| 產(chǎn)品編號 | bs-8047R |
| 英文名稱 | JMJD5 Rabbit pAb |
| 中文名稱 | 組蛋白去甲基化酶JMJD5抗體 |
| 別 名 | JmjC domain-containing protein 5; JMJD5; JMJD5 protein; jumonji domain containing 5; Jumonji domain-containing protein 5; KDM8_HUMAN; Lysine-specific demethylase 8. |
| 研究領(lǐng)域 | 細(xì)胞生物 染色質(zhì)和核信號 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 47 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human JMJD5: 344-416/416 |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009].
Function: Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. Subcellular Location: Nucleus. Tissue Specificity: Weakly expressed in most cells. Highly expressed in breast cancer cells. Similarity: Contains 1 JmjC domain. SWISS: Q8N371 Gene ID: 79831 Database links: Entrez Gene: 79831 Human Entrez Gene: 77035 Mouse Omim: 611917 Human SwissProt: Q8N371 Human SwissProt: Q9CXT6 Mouse Unigene: 145717 Human |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (human gastric carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (JMJD5) Polyclonal Antibody, Unconjugated (bs-8047R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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