| 產(chǎn)品編號(hào) | D56121 |
| 英文名稱 | MMRi62 |
| 中文名稱 | |
| 別 名 | 7-[(2; 3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol |
| 克 隆 號(hào) | |
| CAS | 352693-80-2 |
| 理論分子量 | 396.27 kDa |
| 檢測(cè)分子量 | |
| 保存條件 | Powder: -20℃ for 3 years | In solvent: -80℃ for 1 year |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
MMRi62, a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12. |
