| 產(chǎn)品編號(hào) | bs-11325R-Gold |
| 英文名稱(chēng) | Rabbit Anti-Nova2/Gold Conjugated antibody |
| 中文名稱(chēng) | 膠體金標(biāo)記的神經(jīng)腫瘤Nova2抗原抗體 |
| 別 名 | ANOVA; Astrocytic NOVA1 like RNA binding protein; Gm1424; NOVA2_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 細(xì)胞類(lèi)型標(biāo)志物 表觀遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Nova2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: Nova-1 and Nova-2 are members of a superfamily of protein regulators of RNA metabolism in neurons. Both are nuclear RNA binding proteins with K homology motifs, conserved protein sequences which bind to RNA (1,2). Nova proteins, normally sequestered in the central nervous system, are expressed by systemic tumors in patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA) (3,4). Nova-1 is expressed in the hindbrain and ventral spinal cord and Nova-2 is expressed in the neocortex and hippocampus (4). Nova-1 is necessary for regulating neuron-specific alternative splicing of the glycine receptor Alpha2 pre-mRNA (5). Function: NOVA2 may regulate RNA splicing or metabolism in a specific subset of developing neurons. It binds single strand RNA. Subunit: Interacts with PTBP2; the interaction is direct (By similarity). Subcellular Location: Nucleus. Tissue Specificity: Brain. Expression restricted to astrocytes. Similarity: Contains 3 KH domains. Database links: Entrez Gene: 4858 Human Entrez Gene: 384569 Mouse Omim: 601991 Human SwissProt: Q9UNW9 Human Unigene: 375439 Human Unigene: 262724 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
